Is it possible to host different directories of a website on different servers?

If I wanted to host http://www.xyz.com/abc/ on one server and http://www.xyz.com/def/ on another, could I? I know there are options for load balancing, but that's not why I want to separate them.

web

Load balancing is for distribution of bandwidth and resource usage. You would need to define this on either the DNS mapping or through a forward on domain settings on the server.